Psychologie und Psychiatrie

International Journal of Legal Medicine -     

Ödembildung durch arsenige Säure

Zusammenfassung An der überlebenden Extremität entwickelt sich bei Durchblutung mit Natriumarsenit ein mächtiges Ödem. Das Ödem bleibt aus, wenn man den Durchblutungsdruck auf die Hälfte herabsetzt. An der überlebenden Leber findet sich die Erscheinung nicht.Nach As₂O₃-Zusatz sinkt der kolloidosmotische Druck des Serums, und zwar nur, wenn das Blut mit der Extremität in Berührung war. Der Abfall des kolloidosmotischen Druckes wird als Ursache des Ödems angesehen.Wir haben demnach an der überlebenden Extremität auf drei Arten Ödem erzeugen können: 1. durch arteriellen Hochdruck, 2. durch venöse Stauung, 3. durch Herabsetzung des kolloidosmotischen Druckes.     

Presence of beta human papillomaviruses in nonmelanoma skin cancer from organ transplant recipients and immunocompetent patients in the West of Scotland

Background  Nonmelanoma skin cancer (NMSC) has been linked to cutaneous human papillomaviruses of the genus beta (betaPV).
Objectives  We sought to assess the presence of betaPV in NMSC biopsies from a group of Scottish skin cancer patients, both immunocompetent (IC) patients and immunosuppressed (IS) organ transplant recipients.
Methods  One hundred and twenty-one paraffin-embedded skin tumours (27 actinic keratosis, 41 intraepidermal carcinoma, 53 squamous cell carcinoma) and 11 normal skin samples were analysed for the presence of betaPV by a polymerase chain reaction–reverse hybridization assay designed to detect the presence of the 25 known betaPV genotypes.
Results  In IC patients, betaPV was detected in 30 of 59 (51%) tumours and two of 11 (18%) normal skin samples ( P  =   0·046). In IS patients, betaPV was found in 27 of 62 (44%) tumours; no normal skin samples were available for comparison. The most frequently found genotypes were HPV-24, HPV-15 and HPV-38. Of those tumours infected with betaPV, 28 of 57 (49%) were infected with more than one genotype (range 2–8). Tumours from IS patients were from a younger age group (mean age 57·4 years) than IC patients (mean age 73·8 years). Multiple infections were more common in tumours from IC patients (21 of 30; 70%) compared with those from IS patients (seven of 27; 26%) ( P  <   0·001). In the IC group, age did not appear to influence the distribution of single and multiple infections whereas in IS patients the proportion of multiple infections to single infections increased with age. There were no multiple infections in normal skin.
Conclusions  A wide spectrum of betaPV types was detected in our samples. Further characterization of betaPV in vivo is needed in order to determine the mechanisms by which the virus contributes to cutaneous carcinogenesis.